The use of anabolic androgenic steroids has become synonymous with recreational athletes at every level. However, steroid use has demonstrated an expanding role in society due to their ready availability and perception of safety. With the inherent ability to drastically enhance the athletic performance of those who take them, anabolic steroids have exponentially grown in popularity. Unfortunately, researchers have recently discovered evidence that suggests anabolic steroids may demonstrate potentially new and serious adverse consequences. Evidence obtained from a clinical trial suggests that acute pancreatitis and acute kidney injury are the result of the recreational use of anabolic steroids like methandrostenolone.
Methandrostenolone, otherwise known as metandienone, methandienone, Averbol, Dianabol, Danabol or DBOL, is an anabolic steroid that is readily available for those seeking to enhance their athletic performance or their aesthetic characteristics. As an anabolic androgenic steroid, methandrostenolone displays two distinct, but similar, types of effects. More specifically it promotes anabolism (cell growth), and it affects the development and maintenance of masculine characteristics. In doing so, steroids mimic the effects of both testosterone and dihydrotestosterone. As a result, they have the inherent ability to significantly increase the process of protein synthesis within cells and eventually lead to the development of cellular tissue in muscles.
However, it is common knowledge that steroids may cause cholestatic, a complication characterized by the inability of bile to flow from the liver to the duodenum. As a result, an individual may develop jaundice. Unfortunately, steroids such as methandrostenolone may also significantly increase the risk of developing severe, life-threatening complications.
Despite their ability to provide significant muscle growth, anabolic steroids may be attributed to a number of severe complications. Information gathered from a recent clinical trial indicates that the use of anabolic steroids like methandrostenolone may significantly increase the risk of developing acute pancreatitis and acute kidney injury.
The clinical tiral observed a 50-year-old man of Indian descent who had been on a strict regimen of methandrostenolone. For a total of eight weeks, the subject had been taking 10 mg orally twice a day, five days a week for three weeks and then three times a day, five days a week for the next five weeks. After taking the anabolic steroid for a prolonged period of time, he was admitted to a hospital for further investigation.
Within a couple days of admission, his prognosis began to significantly worsen. He began to experience nausea, vomiting spells, and abdominal pain. Tests revealed that the patients clinical picture was consistent with that of acute pancreatitis. Further investigation lead to a liver biopsy that revealed moderately severe acute cholestasis consistent with anabolic steroid use. A renal biopsy was also necessary in order to determine the full effects of the anabolic steroids. The renal biopsy indicated evidence of desquamation of his tubular epithelial cells. Therefore, acute tubular necrosis was confirmed as the etiology of the renal failure.
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